Electron Microscopy

The service group Electron Microscopy covers electron optical and X-ray analytical investigations for all research departements of INM, research groups of the Saarland University of Saarland and external partners. For nanoscale microscopic investigations, transmission electron (TEM) and scanning electron microscopy (SEM) coupled with X-ray spectral analysis is used. TEM lamellae of a wide variety of samples are prepared inside with a focused ion beam (FIB) microscope and further thinned by focussed Argon ion beam (Nanomill) for atomic analytical analysis. Other preparation techniques such as microtomy, electrolytical polishing, ion milling with non-focusing ion beam and sputter coating are also available.

Team Members
Phone: +49 (0)681-9300-135
Phone: +49 (0)681-9300-247

Publications

2023
Lipid-Polymer Hybrid Nanoparticles for mRNA Delivery to Dendritic Cells: Impact of Lipid Composition on Performance in Different Media

Kliesch, Lena | Delandre, Simon | Gabelmann, Aljoscha | Koch, Marcus | Schulze, Kai | Guzmán, Carlos A. | Loretz, Brigitta | Lehr, Claus-Michael

Pharmaceutics , 2023, 14 (12), 2675.
https://www.mdpi.com/1999-4923/14/12/2675

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2022
The inherent antibiotic activity of myxobacteria-derived autofluorescent outer membrane vesicles is switched on and off by light stimulation

Lapuhs, Philipp | Heinrich, Eilien | Garcia, Ronald | Goes, Adriely | Frank, Nicolas | Bollenbach, Lukas | Stibane, Veronika | Kuhn, Thomas | Koch, Marcus | Kiemer, Alexandra K. | Müller, Rolf | Fuhrmann, Kathrin | Fuhrmann, Gregor

Nanoscale , 2022, 14 (47), 17534-17542.
http://dx.doi.org/10.1039/D2NR02743G

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Self-Assembly of Amphiphilic Carbosilane-Based Block Copolymers in Organic Media and Structure Formation in Colloidal Confinement

Hübner, Hanna | Niebuur, Bart-Jan | Büttner, Thomas | Koch, Marcus | Stühn, Bernd | Kraus, Tobias | Scheschkewitz, David | Gallei, Markus

Macromolecules , 2022, 55 (21), 9442-9451.
https://doi.org/10.1021/acs.macromol.2c01853

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Melt Electrowriting of Graded Porous Scaffolds to Mimic the Matrix Structure of the Human Trabecular Meshwork

Włodarczyk-Biegun | Villiou, Maria | Koch, Klaus Peter | Muth, Christina | Wang | Ott | del Campo

ACS Biomaterials Science & Engineering , 2022, 8 (9), 3899-3911.
https://pubs.acs.org/doi/10.1021/acsbiomaterials.2c00623

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Givinostat-Liposomes: Anti-Tumor Effect on 2D and 3D Glioblastoma Models and Pharmacokinetics

Taiarol, Lorenzo | Bigogno, Chiara | Sesana, Silvia | Kravicz, Marcelo | Viale, Francesca | Pozzi, Eleonora | Monza, Laura | Carozzi, Valentina Alda | Meregalli, Cristina | Valtorta, Silvia | Moresco, Rosa Maria | Koch, Marcus | Barbugian, Federica | Russo, Laura | Dondio, Giulio | Steinkühler, Christian | Re, Francesca

Cancers , 2022, 14 (12), 2978.
https://www.mdpi.com/2072-6694/14/12/2978

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Melt Electrowriting enables fabrication of biommetic hierarchical scaffolds

Wlodarczyk-Biegun, Malgorzata | Zielinski, Piotr | Gladysz, Magdalena | Hofman, Anno | Wu, Xixi | Villiou, Maria | Koch, Marcus | del Campo, Aránzazu | Kamperman, Marleen

Tissue Engineering A , 2022, 28 (Suppl. 1), S362-S362.
https://www.liebertpub.com/doi/epdf/10.1089/ten.tea.2022.29025.abstracts

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Crystalline Carbosilane-Based Block Copolymers: Synthesis by Anionic Polymerization and Morphology Evaluation in the Bulk State

Hübner, Hanna | Niebuur, Bart-Jan | Janka, Oliver | Gemmer, Lea | Koch, Marcus | Kraus, Tobias | Kickelbick, Guido | Stühn, Bernd | Gallei, Markus

Macromolecular Chemistry and Physics , 2022, 224 (3), 2200178.
https://onlinelibrary.wiley.com/doi/abs/10.1002/macp.202200178

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Improving the electrical and structural stability of highly piezoresistive nickel–carbon sensor thin films

Schultes, Günter | Cerino, Mario | Lellig, Angela | Koch, Marcus

Journal of Sensors and Sensor Systems , 2022, 11 (1), 137-147.
https://jsss.copernicus.org/articles/11/137/2022/

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The development of alginate-based amperometric nanoreactors for biochemical profiling of living yeast cells

Zolotukhina, E. V. | Katsen-Globa, A. | Koch, Marcus | Fink-Straube, Claudia | Sukmann, T. | Levchenko, M. G. | Silina, Yulia E.

Bioelectrochemistry , 2022, 145 108082.
https://www.sciencedirect.com/science/article/pii/S1567539422000330

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Nano-in-Microparticles for Aerosol Delivery of Antibiotic-Loaded, Fucose-Derivatized, and Macrophage-Targeted Liposomes to Combat Mycobacterial Infections: In Vitro Deposition, Pulmonary Barrier Interactions, and Targeted Delivery

Huck, Benedikt C. | Thiyagarajan, Durairaj | Bali, Aghiad | Boese, Annette | Besecke, Karen F. W. | Hozsa, Constantin | Gieseler, Robert K. | Furch, Marcus | Carvalho-Wodarz, Cristiane | Waldow, Franziska | Schwudke, Dominik | Metelkina, Olga | Titz, Alexander | Huwer, Hanno | Schwarzkopf, Konrad | Hoppstädter, Jessica | Kiemer, Alexandra K. | Koch, Marcus | Loretz, Brigitta | Lehr, Claus-Michael

Advanced Healthcare Materials , 2022, 11 (11), 2102117.
https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.202102117

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