Electron Microscopy

The service group Electron Microscopy covers electron optical and X-ray analytical investigations for all research departements of INM, research groups of the Saarland University of Saarland and external partners. For nanoscale microscopic investigations, transmission electron (TEM) and scanning electron microscopy (SEM) coupled with X-ray spectral analysis is used. TEM lamellae of a wide variety of samples are prepared inside with a focused ion beam (FIB) microscope and further thinned by focussed Argon ion beam (Nanomill) for atomic analytical analysis. Other preparation techniques such as microtomy, electrolytical polishing, ion milling with non-focusing ion beam and sputter coating are also available.

Team Members
Phone: +49 (0)681-9300-135
Phone: +49 (0)681-9300-247

Publications

2022
Targeting extracellular lectins of Pseudomonas aeruginosa with glycomimetic liposomes

Metelkina, Olga | Huck, Benedikt | O'Connor, Jonathan S. | Koch, Marcus | Manz, Andreas | Lehr, Claus-Michael | Titz, Alexander

Journal of Materials Chemistry B , 2022, 10 (4), 537-548.
http://dx.doi.org/10.1039/D1TB02086B

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Bacteriomimetic Liposomes Improve Antibiotic Activity of a Novel Energy-Coupling Factor Transporter Inhibitor

Drost, Menka | Diamanti, Eleonora | Fuhrmann, Kathrin | Goes, Adriely | Shams, Atanaz | Haupenthal, Jörg | Koch, Marcus | Hirsch, Anna K. H. | Fuhrmann, Gregor

Pharmaceutics , 2022, 14 (1), 4.
https://www.mdpi.com/1999-4923/14/1/4

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2021
Yields and Immunomodulatory Effects of Pneumococcal Membrane Vesicles Differ with the Bacterial Growth Phase

Mehanny, Mina | Kroniger, Tobias | Koch, Marcus | Hoppstädter, Jessica | Becher, Dörte | Kiemer, Alexandra K. | Lehr, Claus-Michael | Fuhrmann, Gregor

Advanced Healthcare Materials , 2021, 11 (5), 2101151.
https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.202101151

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An Outer Membrane Vesicle-Based Permeation Assay (OMPA) for Assessing Bacterial Bioavailability

Richter, Robert | Kamal, Mohamed A. M. | Koch, Marcus | Niebuur, Bart-Jan | Huber, Anna-Lena | Goes, Adriely | Volz, Carsten | Vergalli, Julia | Kraus, Tobias | Müller, Rolf | Schneider-Daum, Nicole | Fuhrmann, Gregor | Pagès, Jean-Marie | Lehr, Claus-Michael

Advanced Healthcare Materials , 2021, 11 (5), 2101180.
https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.202101180

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Reliable release testing for nanoparticles with the NanoDis System, an innovative sample and separate technique

Lombardo, Sonia M. | Günday Türeli, Nazende | Koch, Marcus | Schneider, Marc | Türeli, Akif E.

International Journal of Pharmaceutics , 2021, 609 121215.
https://www.sciencedirect.com/science/article/pii/S0378517321010218

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Enhancing the Stabilization Potential of Lyophilization for Extracellular Vesicles

Trenkenschuh, Eduard | Richter, Maximilian | Heinrich, Eilien | Koch, Marcus | Fuhrmann, Gregor | Friess, Wolfgang

Advanced Healthcare Materials , 2021, 11 (5), 2100538.
https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.202100538

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Failure mechanism analysis based on laser-based surface treatments for aluminum-polyamide laser joining

Elahi, Mahdi Amne | Koch, Marcus | Bardon, Julien | Addiego, Frédéric | Plapper, Peter

Journal of Materials Processing Technology , 2021, 298 117318.
https://www.sciencedirect.com/science/article/pii/S0924013621002788

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Towards hybrid one-pot/one-electrode Pd-NPs-based nanoreactors for modular biocatalysis

Koch, Marcus | Apushkinskaya, N. | Zolotukhina, E. V. | Silina, Yulia E.

Biochemical Engineering Journal , 2021, 175 108132.
https://www.sciencedirect.com/science/article/pii/S1369703X21002084

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Scanning electron microscopy preparation of the cellular actin cortex: A quantitative comparison between critical point drying and hexamethyldisilazane drying

Schu, Moritz | Terriac, Emmanuel | Koch, Marcus | Paschke, Stephan | Lautenschläger, Franziska | Flormann, Daniel A.

PLOS ONE , 2021, 16 (7), e0254165-e0254165.
https://pubmed.ncbi.nlm.nih.gov/34234360

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Spray-dried lactose-leucine microparticles for pulmonary delivery of antimycobacterial nanopharmaceuticals

Thiyagarajan, Durairaj | Huck, Benedikt | Nothdurft, Birgit | Koch, Marcus | Rudolph, David | Rutschmann, Mark | Feldmann, Claus | Hozsa, Constantin | Furch, Marcus | Besecke, Karen F. W. | Gieseler, Robert K. | Loretz, Brigitta | Lehr, Claus-Michael

Drug Delivery and Translational Research , 2021, 11 (4), 1766-1778.
https://doi.org/10.1007/s13346-021-01011-7

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