Electron Microscopy

The service group Electron Microscopy covers electron optical and X-ray analytical investigations for all research departements of INM, research groups of the Saarland University of Saarland and external partners. For nanoscale microscopic investigations, transmission electron (TEM) and scanning electron microscopy (SEM) coupled with X-ray spectral analysis is used. TEM lamellae of a wide variety of samples are prepared inside with a focused ion beam (FIB) microscope and further thinned by focussed Argon ion beam (Nanomill) for atomic analytical analysis. Other preparation techniques such as microtomy, electrolytical polishing, ion milling with non-focusing ion beam and sputter coating are also available.

Team Members
Phone: +49 (0)681-9300-135
Phone: +49 (0)681-9300-247

Publications

2020
pH-Dependent morphology and optical properties of lysine-derived molecular biodynamers

Lee, Sangeun | Kaya, Cansu | Jang, Hongje | Koch, Marcus | Loretz, Brigitta | Buhler, Eric | Lehr, Claus-Michael | Hirsch, Anna Katharina Herta

Materials Chemistry Frontiers , 2020, 4 (3), 905-909.
http://dx.doi.org/10.1039/C9QM00651F

Streptococcal Extracellular Membrane Vesicles Are Rapidly Internalized by Immune Cells and Alter Their Cytokine Release

Mehanny, Mina | Koch, Marcus | Lehr, Claus-Michael | Fuhrmann, Gregor

Frontiers in Immunology , 2020, 11 (80), 1-13.
https://www.frontiersin.org/article/10.3389/fimmu.2020.00080

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2019
Hot EVs – How temperature affects extracellular vesicles

Schulz, Eilien | Karagianni, Anna | Koch, Marcus | Fuhrmann, Gregor

European Journal of Pharmaceutics and Biopharmaceutics , 2019, 146 55-63.
http://www.sciencedirect.com/science/article/pii/S0939641119313098

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The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB

Formicola, Beatrice | Dal Magro, Roberta | Montefusco-Pereira, Carlos V. | Lehr, Claus-Michael | Koch, Marcus | Russo, Laura | Grasso, Gianvito | Deriu, Marco A. | Danani, Andrea | Bourdoulous, Sandrine | Re, Francesca

Journal of Nanobiotechnology , 2019, 17 (1), 115_1-7.
https://doi.org/10.1186/s12951-019-0546-3

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Targeted delivery of functionalized PLGA nanoparticles to macrophages by complexation with the yeast Saccharomyces cerevisiae

Kiefer, Ruth | Jurisic, Marijas | Dahlem, Charlotte | Koch, Marcus | Schmitt, Manfred J. | Kiemer, Alexandra K. | Schneider, Marc | Breinig, Frank

Biotechnology and Bioengineering , 2019, 117 (3), 776-788.
https://onlinelibrary.wiley.com/doi/abs/10.1002/bit.27226

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Determination of the Surface Facets of Gold Nanorods in Wet-Coated Thin Films with Grazing-Incidence Wide Angle X-Ray Scattering

Zhang, Peng | Rothkirch, André | Koch, Marcus | Roth, Stephan | Kraus, Tobias

Particle & Particle Systems Characterization , 2019, 36 (12), 1900323_1-6.
https://onlinelibrary.wiley.com/doi/abs/10.1002/ppsc.201900323

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Combining Soft Polysilazanes with Melt-Shear Organization of Core–Shell Particles: On the Road to Polymer-Templated Porous Ceramics

Boehm, Anna K. | Ionescu, Emanuel | Koch, Marcus | Gallei, Markus

Molecules , 2019, 24 (19), 3553.
https://www.mdpi.com/1420-3049/24/19/3553

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Strength of bacterial adhesion on nanostructured surfaces quantified by substrate morphometry

Spengler, Christian | Nolle, Friederike | Mischo, Johannes | Faidt, Thomas | Grandthyll, Samuel | Thewes, Nicolas | Koch, Marcus | Müller, Frank | Bischoff, Markus | Klatt, Michael Andreas | Jacobs, Karin

Nanoscale , 2019, 11 (42), 19713-19722.
http://dx.doi.org/10.1039/C9NR04375F

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Controlled pore collapse to increase solute rejection of modified PES membranes

Zverina, Libor | Koch, Marcus | Andersen, Mads F. | Pinelo, Manuel | Woodley, John M. | Daugaard, Anders E.

Journal of Membrane Science , 2019, 595 117515.
http://www.sciencedirect.com/science/article/pii/S0376738819317351

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Combining cryo-TEM and energy-filtered TEM for imaging organic core-shell nanoparticles and defining the polymer distribution

Weiss, Agnes-Valencia | Koch, Marcus | Schneider, Marc

International Journal of Pharmaceutics , 2019, 570 118650.
http://www.sciencedirect.com/science/article/pii/S0378517319306957

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