Physical Analytics

The service group physical analytics covers electron optical and X-ray analytical investigations for all research departements of INM, research groups of the Saarland University of Saarland and external partners. For nanoscale microscopic investigations, transmission electron (TEM) and scanning electron microscopy (SEM) coupled with X-ray spectral analysis is used. TEM lamellae of a wide variety of samples are prepared inside with a focused ion beam (FIB) microscope and further thinned by focussed Argon ion beam (Nanomill) for atomic analytical analysis. Other preparation techniques such as microtomy, electrolytical polishing, ion milling with non-focusing ion beam and sputter coating are also available.

Aleeza-Farrukh, INM – Leibniz-Institut für Neue Materialien gGmbH
Dr. Marcus Koch
Head of Physical Analytics
Telefon: +49 (0)681-9300-144
Team Members
Phone: +49 (0)681-9300-135
Phone: +49 (0)681-9300-144
Phone: +49 (0)681-9300-247

Publications

2019
Hot EVs – How temperature affects extracellular vesicles

Schulz, Eilien | Karagianni, Anna | Koch, Marcus | Fuhrmann, Gregor

European Journal of Pharmaceutics and Biopharmaceutics , 2019, 146 55-63.
http://www.sciencedirect.com/science/article/pii/S0939641119313098

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The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB

Formicola, Beatrice | Dal Magro, Roberta | Montefusco-Pereira, Carlos V. | Lehr, Claus-Michael | Koch, Marcus | Russo, Laura | Grasso, Gianvito | Deriu, Marco A. | Danani, Andrea | Bourdoulous, Sandrine | Re, Francesca

Journal of Nanobiotechnology , 2019, 17 (1), 115_1-7.
https://doi.org/10.1186/s12951-019-0546-3

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Targeted delivery of functionalized PLGA nanoparticles to macrophages by complexation with the yeast Saccharomyces cerevisiae

Kiefer, Ruth | Jurisic, Marijas | Dahlem, Charlotte | Koch, Marcus | Schmitt, Manfred J. | Kiemer, Alexandra K. | Schneider, Marc | Breinig, Frank

Biotechnology and Bioengineering , 2019, 117 (3), 776-788.
https://onlinelibrary.wiley.com/doi/abs/10.1002/bit.27226

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Determination of the Surface Facets of Gold Nanorods in Wet-Coated Thin Films with Grazing-Incidence Wide Angle X-Ray Scattering

Zhang, Peng | Rothkirch, André | Koch, Marcus | Roth, Stephan | Kraus, Tobias

Particle & Particle Systems Characterization , 2019, 36 (12), 1900323_1-6.
https://onlinelibrary.wiley.com/doi/abs/10.1002/ppsc.201900323

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Controlled pore collapse to increase solute rejection of modified PES membranes

Zverina, Libor | Koch, Marcus | Andersen, Mads F. | Pinelo, Manuel | Woodley, John M. | Daugaard, Anders E.

Journal of Membrane Science , 2019, 595 117515.
http://www.sciencedirect.com/science/article/pii/S0376738819317351

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Strength of bacterial adhesion on nanostructured surfaces quantified by substrate morphometry

Spengler, Christian | Nolle, Friederike | Mischo, Johannes | Faidt, Thomas | Grandthyll, Samuel | Thewes, Nicolas | Koch, Marcus | Müller, Frank | Bischoff, Markus | Klatt, Michael Andreas | Jacobs, Karin

Nanoscale , 2019, 11 (42), 19713-19722.
http://dx.doi.org/10.1039/C9NR04375F

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Combining Soft Polysilazanes with Melt-Shear Organization of Core–Shell Particles: On the Road to Polymer-Templated Porous Ceramics

Boehm, Anna K. | Ionescu, Emanuel | Koch, Marcus | Gallei, Markus

Molecules , 2019, 24 (19), 3553.
https://www.mdpi.com/1420-3049/24/19/3553

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Combining cryo-TEM and energy-filtered TEM for imaging organic core-shell nanoparticles and defining the polymer distribution

Weiss, Agnes-Valencia | Koch, Marcus | Schneider, Marc

International Journal of Pharmaceutics , 2019, 570 118650.
http://www.sciencedirect.com/science/article/pii/S0378517319306957

Bioinspired Liposomes for Oral Delivery of Colistin to Combat Intracellular Infections by Salmonella enterica

Menina, Sara | Eisenbeis, Janina | Kamal, Mohamed Ashraf M. | Koch, Marcus | Bischoff, Markus | Gordon, Sarah | Loretz, Brigitta | Lehr, Claus-Michael

Advanced Healthcare Materials , 2019, 8 (17), 1900564.
https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.201900564

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Toll-Like Receptor 2 Release by Macrophages: An Anti-inflammatory Program Induced by Glucocorticoids and Lipopolysaccharide

Hoppstädter, Jessica | Dembek, Anna | Linnenberger, Rebecca | Dahlem, Charlotte | Barghash, Ahmad | Fecher-Trost, Claudia | Fuhrmann, Gregor | Koch, Marcus | Kraegeloh, Annette | Huwer, Hanno | Kiemer, Alexandra K.

Frontiers in Immunology , 2019, 10 (1634), 1-17.
https://www.frontiersin.org/article/10.3389/fimmu.2019.01634

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