The surface of the medical grade titanium alloy (Ti–6Al–4V) was modified using a millisecond laser to alter the topography and wetting behavior. We combined anisotropic surface patterning with a nitriding process which is essential for the protection of dental implants against corrosion and wear. While a homogenous nitride layer was achieved, the laser induced a surface topography composed of both micro- and nano-structures. The surface topography leads to anisotropy in wetting which is desired in next generation implant applications such as nature-analogue anisotropic dental restoration.